BPC-157 is a synthetic 15-amino-acid peptide derived from a sequence in a human gastric juice protein. Research consists almost entirely of rodent and cell studies, with very limited human data [1][2].
In endothelial cell and rat studies, BPC-157 increased VEGFR2 expression and internalization and activated the VEGFR2-Akt-eNOS signaling pathway, which researchers linked to increased vessel formation [3]. In cultured rat tendon fibroblasts it increased growth hormone receptor expression, and added growth hormone then activated JAK2 signaling and cell proliferation [5]. Interactions with the nitric oxide system and other pathways have been proposed from rodent work but are not established [1][2].
| Study | Model | Reported result | Source |
|---|---|---|---|
| Achilles detachment model [4] | Rat Achilles tendon surgically detached from bone, rats; with and without corticosteroid | Researchers measured higher load to failure, stiffness and Young's modulus, more organized collagen fibers, and higher collagen type I than controls. | Peer-reviewed J Orthop Res 2006 |
| VEGFR2 and vessel formation [3] | Rat Hind-limb ischemia model in rats, plus chick embryo membrane assay and human endothelial cell culture | Faster blood-flow recovery on laser Doppler, more vessels on histology, higher VEGFR2 mRNA and protein; VEGF-A unchanged in cells. | Peer-reviewed J Mol Med 2017 |
| Growth hormone receptor in tendon cells [5] | Cell Rat Achilles tendon fibroblasts in culture | Growth hormone receptor mRNA and protein increased in a dose- and time-dependent way; added growth hormone then increased proliferation and JAK2 activation. | Peer-reviewed Molecules 2014 |
| Pharmacokinetics and excretion [6] | Other animal Rats and beagle dogs, single and repeated dosing, radiolabeled tracing | Elimination half-life under 30 minutes in both species (15.2 min rat, 5.27 min dog); broken down into small fragments and amino acids, mainly proline. | Peer-reviewed Front Pharmacol 2022 |
| Intestinal anastomosis research [7] | Review Review of rat studies of surgical intestinal, nerve and vessel anastomoses and fistula models | Summarizes Sikiric-group rat studies reporting anastomosis and fistula closure outcomes; no pooled numbers reported. | Peer-reviewed Pharmaceuticals 2024 |
| Pilot safety study in adults [8] | Human Adults, open-label safety pilot, 2 participants | Design-level only. Published 2025 in Altern Ther Health Med; independent reviewers note the very small size. | Peer-reviewed Altern Ther Health Med 2025 |
Human trials are listed for research context only; outcomes are reported in the linked publications. Animal and lab results do not establish effects in humans.
PureLab supplies BPC-157 for laboratory research. Lot-specific certificates of analysis are posted on the product page as they are issued.
View research-grade BPC-157