Also known as: Delta sleep-inducing peptide
Delta sleep-inducing peptide (DSIP) is a short neuropeptide first described in the 1970s. Research consists of small, older human sleep-laboratory studies and a modest number of rodent studies; its mechanism remains unresolved.
How DSIP acts is not established: no specific receptor has been confirmed, and a 2006 review described it as a still unresolved riddle [1]. In a 2024 mouse study, researchers measured changes in serum melatonin and serotonin after DSIP, which the authors proposed as possible contributors to the observed sleep and behavior changes [2]. These links are proposed, not demonstrated.
| Study | Model | Reported result | Source |
|---|---|---|---|
| DSIP and fusion peptide in a PCPA mouse model [2] | Mouse Sleep-disruption model (PCPA), male Kun-Ming mice, n=6 per group | Researchers measured daily wakefulness and serum melatonin and serotonin versus model-only mice. | Peer-reviewed Frontiers in Pharmacology 2024 |
| DSIP in a rat focal-ischemia model [3] | Rat Focal ischemia-reperfusion (MCAO, 90 min), male Sprague-Dawley rats, n=26 | Rotarod fall latency rose from 11 to 25 s over 21 days in DSIP group; infarct volume difference vs vehicle (20.9% vs 24.1%) was not significant. | Peer-reviewed Molecules 2021 |
| DSIP sleep-laboratory study [4] | Human 16 adults, double-blind, matched-pairs, placebo-controlled, 5 laboratory nights | Endpoints: polysomnographic measures. Published. | Peer-reviewed Neuropsychobiology 1992 |
| DSIP and 24-hour sleep-wake behavior [5] | Human 14 middle-aged adults, double-blind, placebo-controlled, 7 nights | Endpoints: polysomnographic night sleep, daytime alertness and mental performance. Published. | Peer-reviewed European Neurology 1987 |
| DSIP: a still unresolved riddle [1] | Review Narrative review of DSIP research | Summarizes decades of findings and notes the peptide's mechanism and physiological role remain unresolved. | Peer-reviewed Journal of Neurochemistry 2006 |
Human trials are listed for research context only; outcomes are reported in the linked publications. Animal and lab results do not establish effects in humans.
PureLab supplies DSIP for laboratory research. Lot-specific certificates of analysis are posted on the product page as they are issued.
View research-grade DSIP