Also known as: GnRH
Gonadorelin is a synthetic decapeptide with the same amino acid sequence as natural gonadotropin-releasing hormone (GnRH). It has a long research record, mostly in cattle reproduction studies and human pituitary-function research.
Gonadorelin has the same 10-amino-acid sequence as hypothalamic GnRH (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) and acts on pituitary GnRH receptors to trigger release of LH and FSH [1]. In cattle, researchers measured a rise in serum LH within about 1.35 hours of administration [4]. Because it is the native sequence, it has been compared with longer-acting synthetic GnRH analogs such as buserelin, which produced higher LH peaks [3].
| Study | Model | Reported result | Source |
|---|---|---|---|
| Comparison of four gonadorelin products [2] | Other animal Lactating dairy cows, randomized to four commercial gonadorelin products (n=132-146 per group; 558 total) | Ovulation of an accessory follicle ranged from 55.3% to 85.0% across products; LH peak, timing and area under the curve did not differ between products. | Peer-reviewed Theriogenology 2009 |
| Gonadorelin vs buserelin in Bos indicus cattle [3] | Other animal Nelore heifers (n=57) and cows (n=53) on day 7 after a prior ovulation; two gonadorelin and two buserelin amounts | Buserelin produced higher LH peaks than gonadorelin; in heifers, ovulation was 88.9% with buserelin vs 16.7% with gonadorelin. | Peer-reviewed Theriogenology 2024 |
| Two gonadorelin amounts vs saline [4] | Other animal Bos indicus heifers and cows (n=114), randomized: untreated, saline, or one of two gonadorelin amounts | Both gonadorelin groups had higher serum LH than saline (P<0.001); new corpus luteum formation by day 5 (about 14%) did not differ from saline (12.5%). | Peer-reviewed Aust Vet J 2022 |
| Pulsatile GnRH cohort in men [5] | Human Adult men, retrospective, single center, no control group (n=54); mean follow-up 15.9 months | Endpoints: reproductive-axis hormone measures over 24 months. Published. | Peer-reviewed Transl Androl Urol 2025 |
Human trials are listed for research context only; outcomes are reported in the linked publications. Animal and lab results do not establish effects in humans.
PureLab does not supply this compound. This page summarizes published research only.
