Also known as: Decorinyl
Tripeptide-10 citrulline (trade name Decorinyl) is a synthetic short peptide designed to mimic the collagen-binding region of decorin, used as a cosmetic ingredient. Research consists of in-vitro collagen-fiber work and small cosmetic trials.
Decorin is a small proteoglycan that binds collagen fibrils and regulates their diameter. Tripeptide-10 citrulline was selected from a library of peptides mimicking decorin's collagen-binding sequences [1]. In vitro it regulated collagen fibrillogenesis, producing thinner, more uniform fibrils [1][4]; whether this occurs in living skin is not established.
| Study | Model | Reported result | Source |
|---|---|---|---|
| Decorin-mimetic design study [1] | Cell In-vitro collagen fibrillogenesis assay, peptide library screen | Selected peptide reduced collagen fibril diameter and increased uniformity in vitro. | Peer-reviewed Int J Cosmet Sci 2008 |
| Combination cream trial [2] | Human 24 women, randomized, placebo-controlled, four arms (alone, with acetyl hexapeptide-3, comparator, placebo), 60 days | Endpoints: skin microtopography (roughness), water loss, self-evaluation, tolerability. Published. | Peer-reviewed J Cosmet Dermatol 2017 |
| Topical peptide review [3] | Review Narrative review | Summarizes an assessor-blinded, placebo-controlled supplier study of 43 volunteers measuring skin suppleness. | Peer-reviewed Cosmetics 2017 |
| Skin-peptide review [4] | Review Narrative review | Describes decorin mimicry and in-vitro fibril organization data. | Peer-reviewed Biomolecules 2025 |
| Bioactive oligopeptides review [5] | Review Narrative review | Lists sequence and decorin-binding rationale; notes combination study with acetyl hexapeptide-3. | Peer-reviewed J Appl Biomater Funct Mater 2025 |
Human cosmetic studies describe appearance only. Lab results do not establish effects on skin structure.
