5-Amino-1MQ (5-amino-1-methylquinolinium) is a highly membrane-permeable small-molecule research compound primarily studied as a potent and selective inhibitor of Nicotinamide N-Methyltransferase (NNMT). In preclinical laboratory models, 5-Amino-1MQ has shown the ability to preserve intracellular NAD⁺ levels, promote favorable shifts in adipose tissue metabolism, support mitochondrial function, and enhance markers of muscle performance and metabolic health. With its excellent bioavailability and targeted mechanism, this research compound is actively explored by scientists investigating body composition, insulin sensitivity, and longevity-related pathways.
FOR RESEARCH USE ONLY. 5-Amino-1MQ is supplied strictly for laboratory and scientific research purposes. It is not for human consumption and has not been evaluated by the FDA.
5-Amino-1MQ (NNMT inhibitor) research compound — in-depth guide to preclinical studies on NAD+ preservation, adipose tissue remodeling, muscle strength, mitochondrial function and metabolic longevity pathways. Strictly supplied for laboratory research use only.
5-Amino-1MQ, chemically known as 5-amino-1-methylquinolinium, is a small-molecule quinolinium derivative developed as a potent and highly selective inhibitor of the enzyme Nicotinamide N-Methyltransferase (NNMT). Researchers are actively studying this compound in cell culture, tissue explants, and animal models because of its ability to modulate key metabolic regulators without requiring dietary intervention.
In preclinical models, 5-Amino-1MQ inhibits NNMT → prevents excessive methylation of nicotinamide → preserves intracellular NAD+ pools → supports enhanced mitochondrial respiration and downstream metabolic signaling.
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1. NNMT Inhibition & NAD+ Preservation Multiple independent laboratory studies have reported robust NNMT blockade and sustained NAD+ elevation in adipose, liver, and muscle tissues.
2. Adipose Tissue & Body Composition Models In diet-induced obesity rodent models, 5-Amino-1MQ treatment was associated with reduced adipocyte hypertrophy and favorable shifts in fat distribution.
3. Skeletal Muscle Strength & Regeneration Aged mouse studies showed improvements in grip strength, treadmill endurance, and markers of muscle regeneration after administration of the compound.
4. Mitochondrial Function & Insulin Sensitivity Enhanced oxygen consumption rates and improved glucose handling parameters have been documented in cellular and whole-animal metabolic assays.
5. Broader Metabolic Longevity Pathways Researchers are exploring how NNMT inhibition intersects with sirtuin activity, AMPK signaling, and other longevity-related cascades.
5-Amino-1MQ is sold strictly for laboratory and scientific research use only. It has not undergone human clinical trials, is not approved for human consumption, and has not been evaluated by the FDA or any other regulatory agency for safety or efficacy in humans.
FOR RESEARCH USE ONLY • NOT FOR HUMAN CONSUMPTION Not evaluated by the FDA • For laboratory and scientific research purposes only.
Q1: What is the primary molecular target of 5-Amino-1MQ? A: Nicotinamide N-Methyltransferase (NNMT).
Q2: How does 5-Amino-1MQ differ from NAD+ precursors like NMN or NR? A: It works upstream by preventing NAD+ consumption rather than providing more precursor material.
Ready to add to your cart for your lab? All products are third-party tested, shipped with COA, and supplied exclusively for research purposes.
Related Research Compounds: BPC-157 • TB-500 (Wolverine Stack) • 5-Amino-1MQ • Epitalon • etc.
| Size | 10MG, 50MG |
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