A short synthetic peptide matching the tail end (C-terminal region) of human growth hormone. Published research is old and sparse: lab and rodent studies from the 1990s and early 2000s, mostly on the closely related modified fragment AOD9604.
Early lab work reported that a synthetic peptide matching hGH residues 177-191 reduced fat synthesis (lipogenesis) with activity similar to intact growth hormone [1]. Later rodent studies used AOD9604, a modified C-terminal hGH fragment, and found it raised fat oxidation and plasma glycerol, a marker of fat breakdown [2][3]. Unlike full growth hormone, AOD9604 did not compete for the growth hormone receptor or trigger cell proliferation in lab assays [2]. Whether results for AOD9604 apply to the unmodified 176-191 sequence has not been directly tested in published work located.
| Study | Model | Reported result | Source |
|---|---|---|---|
| Ng et al., AOD9604 in rats [4] | Rat Zucker (fa/fa) rats, 19 days, vs untreated controls | Body weight gain 15.8 g vs 35.6 g in controls; increased lipolytic activity in fat tissue; insulin sensitivity not adversely affected (clamp) | Peer-reviewed Horm Res 2000 |
| Heffernan et al., fat oxidation [2] | Mouse ob/ob and lean C57BL/6J mice, 14 days, compared with full hGH; plus receptor-binding cell assay | Reduced weight gain and raised fat oxidation and plasma glycerol; unlike hGH, no rise in blood glucose and no hGH-receptor binding | Peer-reviewed Int J Obes 2001 |
| Beta-3 receptor knockout study [3] | Mouse ob/ob mice and beta-3 adrenergic receptor knockout mice, chronic exposure, compared with full hGH | Researchers measured lipid metabolism markers in both strains to test whether the beta-3 adrenergic receptor is required | Peer-reviewed Endocrinology 2001 |
Human trials are listed for research context only; outcomes are reported in the linked publications. Animal and lab results do not establish effects in humans.
PureLab does not carry Fragment 176-191 yet. Research demand decides what we add next; leave your email and we’ll tell you when it’s available.
