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Research compoundMetabolic ResearchIn stock

5-Amino-1MQ

Also known as: NNMT inhibitor (small molecule)

A small molecule (not a peptide) from the methylquinolinium family that blocks the enzyme nicotinamide N-methyltransferase (NNMT). Research is limited to a handful of mouse and cell studies from one academic group.

Evidence: preclinical · Mouse and cell studies only

At a glance

Class
Nicotinamide N-methyltransferase (NNMT) inhibitor; small molecule
Developer
No pharmaceutical developer; studied by an academic group at the University of Texas Medical Branch
FDA status
Not approved by the FDA for any use
Human data
No published human trials found
Animal / lab data
High-fat-diet and aged-muscle mouse models; fat-cell and muscle-cell cultures (2018–2022)

Where it’s been studied

1234
  • 1Adipose tissueHigh-fat-diet model, mice (2018, 2022)
  • 2Skeletal muscleInjury model in 24-month-old mice (2019)
  • 3Gut microbiomeHigh-fat-diet model, mice (2022)
  • 4Fat and muscle cellsAdipocyte and C2C12 myoblast cultures (2018, 2019)

Mechanism studied

5-amino-1MQ blocks NNMT, an enzyme that uses up nicotinamide and the methyl donor SAM to make 1-methylnicotinamide [1]. In cultured fat cells, blocking NNMT lowered 1-methylnicotinamide and raised NAD+ and SAM, and it did not inhibit related methyltransferases or NAD+ salvage enzymes [1]. Researchers propose that the shift in NAD+ balance underlies the fat-cell and muscle-stem-cell effects seen in mice; this remains a hypothesis [2].

What the research shows

StudyModelReported resultSource
NNMT inhibitors in fat cells [1]Cell
Cultured adipocytes		Lower intracellular 1-methylnicotinamide, higher NAD+ and SAM, and reduced lipogenesis (fat synthesis)Peer-reviewed
Biochem Pharmacol 2018
High-fat-diet model [1]Mouse
High-fat diet model, systemic dosing vs vehicle		Researchers measured adipose-tissue markers, plasma lipids and food intake versus vehicle.Peer-reviewed
Biochem Pharmacol 2018
Aged muscle injury model [2]Mouse
24-month-old mice, barium-chloride muscle injury, 1–3 weeks		Muscle stem cell activity increased; fiber cross-sectional area about 2-fold vs controls; peak torque about 70% higherPeer-reviewed
Biochem Pharmacol 2019
Diet switch plus NNMT inhibition [3]Mouse
High-fat-diet mice switched to low-fat diet, vs lean controls		Researchers compared adipose and gut-microbiome measures with lean controls; Lactobacillus increased, Erysipelatoclostridium decreased.Peer-reviewed
Sci Rep 2022

Human trials are listed for research context only; outcomes are reported in the linked publications. Animal and lab results do not establish effects in humans.

Verified by third-party testing

CertificatePosted on the product page
TestingIndependent, third-party

Research-grade supply

PureLab supplies 5-Amino-1MQ for laboratory research. Lot-specific certificates of analysis are posted on the product page as they are issued.

View research-grade 5-Amino-1MQ

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Sources

  1. Neelakantan H et al. (2018). doi:10.1016/j.bcp.2017.11.007 Source
  2. Neelakantan H et al. (2019). doi:10.1016/j.bcp.2019.02.008 Source
  3. Dimet-Wiley A et al. (2022). doi:10.1038/s41598-021-03670-5 Source
For research use only. Not for human or veterinary use. Not a drug, food or cosmetic, and not intended to diagnose, treat, cure or prevent any disease. This library summarizes published research for educational purposes. PureLab Performance Inc.