Also known as: Mod GRF 1-29 (no DAC); CJC-1295 with DAC
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH 1-29). The published studies cover the 'with DAC' version, which binds albumin to extend its half-life; the 'no DAC' form (Mod GRF 1-29) has little dedicated peer-reviewed research. Data consist of early human pharmacology studies and rat work.
Established: CJC-1295 is built on the first 29 amino acids of GHRH and acts on the GHRH (GRF) receptor of the anterior pituitary, as shown in rats [1]. Established: the DAC (drug affinity complex) version binds circulating albumin, designed to extend its time in circulation; pharmacokinetics were measured in adults [2]. Reported: GH release remained pulsatile during continuous exposure [3]. These findings come from the DAC form; the no-DAC form lacks the albumin link and is expected to be much shorter-acting, but dedicated studies were not identified.
| Study | Model | Reported result | Source |
|---|---|---|---|
| Albumin-binding GRF(1-29) conjugates [1] | Rat Rats; GRF(1-29)-albumin bioconjugates tested on anterior pituitary GRF receptor | Researchers reported that albumin-bound GRF(1-29) conjugates activated the pituitary GRF receptor, leading to selection of CJC-1295. | Peer-reviewed Endocrinology 2005 |
| Single and repeat escalating-exposure trials [2] | Human Adults, randomized, double-blind, placebo-controlled trials (2006) | Primary endpoints: peak and area-under-curve GH and IGF-I, plus pharmacokinetics. Published. | Peer-reviewed J Clin Endocrinol Metab 2006 |
| GH pulsatility during CJC-1295 exposure [3] | Human Adults; frequent GH sampling during continuous CJC-1295 exposure | Endpoint: pattern of GH secretion (pulsatility). Published. | Peer-reviewed J Clin Endocrinol Metab 2006 |
Human trials are listed for research context only; outcomes are reported in the linked publications. Animal and lab results do not establish effects in humans.
PureLab supplies CJC-1295 for laboratory research. Lot-specific certificates of analysis are posted on the product page as they are issued.
View research-grade CJC-1295